America’s most famous letter-turner is helping spell out the risks of heart disease, the No. 1 killer of women.

Vanna White, who has worn more than 6,000 outfits since she started on “Wheel of Fortune” in 1982, will wear a red dress on the May 5 episode to spread the word about the American Heart Association’s Go Red For Women movement.

The episode is timed to air just before Mother’s Day — fitting because her late mom, Joan White, raised funds for the association in the 1970s.

“My mother was a huge supporter of the American Heart Association,” said White, 57. “She would stay up for a whole weekend raising money on air for WNMB [radio station] in North Myrtle Beach, South Carolina, because it was so important to her. She’d literally stay on air 24 hours a day Friday until Sunday.”

White, who averages 720 claps an episode, is known for cheering on contestants as they try and solve puzzles. Her enthusiasm could also help viewers learn about cardiovascular disease, which kills about the same number of women as the next three causes of death combined, including all forms of cancer.

“I would love to encourage women to be aware and to take better care of themselves,” she said. “Knowing that heart disease is the No. 1 killer is important. I hope we can get the awareness out there.”

Check local listings for details on the May 5 episode of “Wheel of Fortune.”